The Intestinal Microenvironment and Functional Gastrointestinal Disorders.
Identifieur interne : 001617 ( Main/Exploration ); précédent : 001616; suivant : 001618The Intestinal Microenvironment and Functional Gastrointestinal Disorders.
Auteurs : Giovanni Barbara [Italie] ; Christine Feinle-Bisset [Australie] ; Uday C. Ghoshal [Inde] ; Eamonn M. Quigley [États-Unis] ; Javier Santos [Espagne] ; Steve Vanner [Canada] ; Nathalie Vergnolle [France] ; Erwin G. Zoetendal [Pays-Bas]Source :
- Gastroenterology [ 1528-0012 ] ; 2016.
Abstract
For decades, interactions between the enteric neuromuscular apparatus and the central nervous system have served as the primary focus of pathophysiological research in the functional gastrointestinal disorders. The accumulation of patient reports, as well as clinical observations, has belatedly led to an interest in the role of various luminal factors and their interactions with each other and the host in functional gastrointestinal disorders. Most prominent among these factors has been the role of food. As a consequence, while not always evidence-based, dietary interventions are enjoying a renaissance in irritable bowel syndrome management. Not surprisingly, given its exploration in many disease states, the gut microbiota has also been studied in functional gastrointestinal disorders; data remain inconclusive. Likewise, there is also a considerable body of experimental and some clinical data to link functional gastrointestinal disorders pathogenesis to disturbances in epithelial barrier integrity, abnormal entero-endocrine signaling and immune activation. These data provide growing evidence supporting the existence of micro-organic changes, particularly in subgroups of patients with functional dyspepsia and IBS. However, their exact role in the complex pathophysiology and symptom generation of functional gastrointestinal disorders needs to be further studied and elucidated particularly with longitudinal and interventional studies.
DOI: 10.1053/j.gastro.2016.02.028
PubMed: 27144620
Affiliations:
- Australie, Canada, Espagne, France, Inde, Italie, Pays-Bas, États-Unis
- Australie-Méridionale, Catalogne, Gueldre (province), Midi-Pyrénées, Occitanie (région administrative), Texas
- Barcelone, Toulouse, Wageningue
- Université de Wageningue
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Ghoshal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author><author><name sortKey="Quigley, Eamonn M" sort="Quigley, Eamonn M" uniqKey="Quigley E" first="Eamonn M" last="Quigley">Eamonn M. Quigley</name><affiliation wicri:level="2"><nlm:affiliation>Lynda K and David M Underwood Center for Digestive Disorders, Division of Gastroenterology and Hepatology, Houston Methodist Hospital and Weill Cornell Medical College, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lynda K and David M Underwood Center for Digestive Disorders, Division of Gastroenterology and Hepatology, Houston Methodist Hospital and Weill Cornell Medical College, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Santos, Javier" sort="Santos, Javier" uniqKey="Santos J" first="Javier" last="Santos">Javier Santos</name><affiliation wicri:level="3"><nlm:affiliation>Lab Neuro-immune-gastroenterology, Digestive System Research Unit, Department of Gastroenterology, Institut de Recerca Vall d'Hebron, Hospital Vall d'Hebron, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Lab Neuro-immune-gastroenterology, Digestive System Research Unit, Department of Gastroenterology, Institut de Recerca Vall d'Hebron, Hospital Vall d'Hebron, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Vanner, Steve" sort="Vanner, Steve" uniqKey="Vanner S" first="Steve" last="Vanner">Steve Vanner</name><affiliation wicri:level="1"><nlm:affiliation>Gastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Gastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Vergnolle, Nathalie" sort="Vergnolle, Nathalie" uniqKey="Vergnolle N" first="Nathalie" last="Vergnolle">Nathalie Vergnolle</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U1220, Toulouse, France; Université de Toulouse, UPS, Institut de Recherche en Santé Digestive (IRSD), Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1220, Toulouse, France; Université de Toulouse, UPS, Institut de Recherche en Santé Digestive (IRSD), Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Zoetendal, Erwin G" sort="Zoetendal, Erwin G" uniqKey="Zoetendal E" first="Erwin G" last="Zoetendal">Erwin G. Zoetendal</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University</wicri:regionArea><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName><orgName type="university">Université de Wageningue</orgName></affiliation></author></analytic><series><title level="j">Gastroenterology</title><idno type="eISSN">1528-0012</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For decades, interactions between the enteric neuromuscular apparatus and the central nervous system have served as the primary focus of pathophysiological research in the functional gastrointestinal disorders. The accumulation of patient reports, as well as clinical observations, has belatedly led to an interest in the role of various luminal factors and their interactions with each other and the host in functional gastrointestinal disorders. Most prominent among these factors has been the role of food. As a consequence, while not always evidence-based, dietary interventions are enjoying a renaissance in irritable bowel syndrome management. Not surprisingly, given its exploration in many disease states, the gut microbiota has also been studied in functional gastrointestinal disorders; data remain inconclusive. Likewise, there is also a considerable body of experimental and some clinical data to link functional gastrointestinal disorders pathogenesis to disturbances in epithelial barrier integrity, abnormal entero-endocrine signaling and immune activation. These data provide growing evidence supporting the existence of micro-organic changes, particularly in subgroups of patients with functional dyspepsia and IBS. However, their exact role in the complex pathophysiology and symptom generation of functional gastrointestinal disorders needs to be further studied and elucidated particularly with longitudinal and interventional studies.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Inde</li><li>Italie</li><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Australie-Méridionale</li><li>Catalogne</li><li>Gueldre (province)</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Texas</li></region><settlement><li>Barcelone</li><li>Toulouse</li><li>Wageningue</li></settlement><orgName><li>Université de Wageningue</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Barbara, Giovanni" sort="Barbara, Giovanni" uniqKey="Barbara G" first="Giovanni" last="Barbara">Giovanni Barbara</name></noRegion></country><country name="Australie"><region name="Australie-Méridionale"><name sortKey="Feinle Bisset, Christine" sort="Feinle Bisset, Christine" uniqKey="Feinle Bisset C" first="Christine" last="Feinle-Bisset">Christine Feinle-Bisset</name></region></country><country name="Inde"><noRegion><name sortKey="Ghoshal, Uday C" sort="Ghoshal, Uday C" uniqKey="Ghoshal U" first="Uday C" last="Ghoshal">Uday C. Ghoshal</name></noRegion></country><country name="États-Unis"><region name="Texas"><name sortKey="Quigley, Eamonn M" sort="Quigley, Eamonn M" uniqKey="Quigley E" first="Eamonn M" last="Quigley">Eamonn M. Quigley</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Santos, Javier" sort="Santos, Javier" uniqKey="Santos J" first="Javier" last="Santos">Javier Santos</name></region></country><country name="Canada"><noRegion><name sortKey="Vanner, Steve" sort="Vanner, Steve" uniqKey="Vanner S" first="Steve" last="Vanner">Steve Vanner</name></noRegion></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Vergnolle, Nathalie" sort="Vergnolle, Nathalie" uniqKey="Vergnolle N" first="Nathalie" last="Vergnolle">Nathalie Vergnolle</name></region></country><country name="Pays-Bas"><region name="Gueldre (province)"><name sortKey="Zoetendal, Erwin G" sort="Zoetendal, Erwin G" uniqKey="Zoetendal E" first="Erwin G" last="Zoetendal">Erwin G. Zoetendal</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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